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ASH 2015 | Alisertib for the treatment of peripheral T-cell lymphoma

Name: Alisertib for the treatment of peripheral T-cell lymphoma
Uploaded: 2015-12-04T00:00:00.000Z
Duration: 5 min 9 s

Owen O'Connor • 4 Dec 2015

ASH 2015

T-Cell Lymphoma Alisertib Gemcitabine Pralatrexate Romidepsin

Owen A O’Connor, MD, PhD from the Columbia University Medical Center Center for Lymphoid Malignancies, New York, NY, presents the results of the first multicenter, randomized Phase III study (NCT01482962) in patients with relapsed/refractory (R/R) peripheral T-cell lymphoma (PTCL), which evaluated alisertib vs the investigator’s choice (pralatrexate, romidepsin or gemcitabine). Alisertib is a selective inhibitor of Aurora A kinase but it was not found to be superior to the comparator arm in terms of progression-free survival (PFS). He explains some of the key findings and also talks about data from another study showing a synergy between alisertib and romidepsin.
The results were presented at the American Society of Hematology (ASH) 2015 Annual Meeting in Orlando, FL.