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ASH 2023 | BMT CTN 1506/MORPHO: FLT3-ITD variant allele frequency and MRD data
Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, discusses a post-hoc analysis of measurable residual disease (MRD) from the BMT CTN 1506/MORPHO study (NCT02997202) of gilteritinib in patients with FLT3-ITD mutated acute myeloid leukemia (AML). Dr Levis outlines the findings regarding FLT3-ITD variant allele frequency and how this relates to survival of patients, and highlights that a previously unknown aspect of AML disease biology was uncovered through this study. A unique quantitative assay was also specifically designed for measuring MRD in this trial. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Research Funding: FujiFilm, Astellas Global Pharma
Consultancy: Takeda, Menarini, Jazz, Daiichi-Sankyo, Bristol Myers Squibb, Amgen, Abbvie, Pfizer
