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EBMT 2020 | Transplantation: a holistic approach

Jaap Jan Boelens, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses approaching transplantation holistically, exploring conditioning regimens and GvHD. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc).

Transcript (edited for clarity)

So I always considered transplant as an package therapy so it’s not just the cells you throw in, but you have to consider also the conditioning regimens. And optimizing the conditioning regimens can influence and can impact also the effects, the cells you throw in on day zero, and also the GvHD, or let’s say prophylaxis, you should get after transplant is important for the ultimate outcome...

So I always considered transplant as an package therapy so it’s not just the cells you throw in, but you have to consider also the conditioning regimens. And optimizing the conditioning regimens can influence and can impact also the effects, the cells you throw in on day zero, and also the GvHD, or let’s say prophylaxis, you should get after transplant is important for the ultimate outcome. So I always consider transplant as being a package. And we should, let’s say also, always target that holistically and immune reconstitution, I think that’s the big drive of the outcomes. The ultimate goal should be to get a balanced and predictable immune reconstitution after transplant. Because if you have a better predictable and balanced immune reconstitution, it’s also easier to study interventional therapies after transplant to prevent transplant relapse, because you’ll get rid of a lot of variables in a transplant setting where you already have a lot of variables.

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