COSTEM 2022 | The prognostic impact of pre-transplant MRD-positivity in patients with AML
Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, discusses whether a measurable residual disease (MRD) negative status should be achieved prior to stem cell transplantation (SCT) in patients with acute myeloid leukemia (AML). There is a strong correlation between pre-transplant MRD status and relapse rate, with the field of acute lymphoblastic leukemia (ALL) setting a precedent of administering blinatumomab in MRD-positive patients prior to transplant. Whilst this strategy cannot be directly translated to patients with AML, maintenance therapy consisting of sorafenib is currently used in a number of patients. This interview took place at the 7th Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM) in Berlin, Germany.
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