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EHA 2024 | Should bispecifics or CAR-T be given first in R/R FL?

Martin Hutchings, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, provides an insight into the debate on whether bispecific antibodies or CAR T-cell therapy should be given as the first immunotherapy in patients with relapsed/refractory (R/R) follicular lymphoma (FL). In most patients, bispecific antibodies will be the better option initially, as they tend to confer a more favorable safety profile and can be combined with a range of agents to improve treatment efficacy. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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Disclosures

Research Funding: Takeda, Roche and Genmab, Celgene, Novartis; Consultancy: Takeda, Roche and Genmab, Celgene, Novartis, AbbVie, AstraZeneca, Janssen, Merck, F. Hoffmann-La Roche Ltd, Bristol Myers-Squibb, Genentech, Incyte; Honoraria: Takeda, Roche and Genmab, Celgene, AbbVie, AstraZeneca, Merck, F. Hoffmann-La Roche Ltd; Membership on an Entity’s Board of Directors or Advisory Committees: Takeda, Roche and Genmab, Celgene, AbbVie, AstraZeneca, Janssen, Merck, F. Hoffmann-La Roche Ltd.