The Chronic Lymphocytic Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), AbbVie (Platinum), BeOne Medicines (Silver) and Lilly (Silver). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
The Lymphoma Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), BMS (Gold), Johnson & Johnson (Gold), Takeda (Silver) and Galapagos (Bronze). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ICML 2023 | Insights into the activity of NX-2127 in patients with R/R B-cell malignancies
Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, gives an overview of the mechanism of action of BTK degraders, and highlights the value of these agents as an option for patients who develop resistance to both covalent and non-covalent BTK inhibitors. Prof. Danilov then discusses a Phase I study evaluating the safety and activity of NX-2127, a novel BTK degrader, in patients with relapsed/refractory (R/R) B-cell malignancies, including chronic lymphocytic leukemia (CLL) and diffuse large B-cell lymphoma (DLBCL). This agent has shown promising preliminary efficacy in this patient population, with a fairly manageable toxicity profile. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.
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Disclosures
A.V.D. has received consulting fees from Abbvie, AstraZeneca, Bayer Oncology, BeiGene, Bristol Meyers Squibb, Genentech, GenMab, Incyte, Lilly Oncology, Nurix, Oncovalent, Pharmacyclics and TG Therapeutics and has ongoing research funding from Abbvie, AstraZeneca, Bayer Oncology, Bristol Meyers Squibb, Cyclacel, MEI Pharma, Nurix, TG Therapeutics and Takeda Oncology.
