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EBMT 2025 | Key diagnostic tests needed to make a definitive diagnosis of AL amyloidosis
In this video, Kiavasch Farid, MD, Heidelberg University Hospital, Heidelberg, Germany, briefly outlines the key diagnostic tests that are needed to make a definitive diagnosis of light chain (AL) amyloidosis, emphasizing that tissue biopsy staining is central in the diagnostic process. This interview took place at the 51st Annual Meeting of the EBMT in Florence, Italy.
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Transcript
So amyloidosis is a whole spectrum of diseases, right? So when we are talking about systemic light chain amyloidosis, tissue is the key. So we need a biopsy, we need Congo red staining and we need a high index of suspicion and that’s the most important thing. And then if there are any symptoms that are suspicious of AL amyloidosis, one should order serum-free light chains, not only serum protein electrophoresis and obviously also immunofixation to provide the diagnosis of monoclonal gammopathy and the most important thing is the staining in the tissue...
So amyloidosis is a whole spectrum of diseases, right? So when we are talking about systemic light chain amyloidosis, tissue is the key. So we need a biopsy, we need Congo red staining and we need a high index of suspicion and that’s the most important thing. And then if there are any symptoms that are suspicious of AL amyloidosis, one should order serum-free light chains, not only serum protein electrophoresis and obviously also immunofixation to provide the diagnosis of monoclonal gammopathy and the most important thing is the staining in the tissue.
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Disclosures
Travel Grants: Pierre Fabre and Kite/Gilead.
