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EBMT 2025 | Key considerations when transplanting a pediatric patient with a non-malignant disorder
In this video, Rawad Rihani, MD, MSc, King Hussein Cancer Center, Amman, Jordan, briefly outlines the key factors to consider when selecting a pediatric patient with a non-malignant disorder for stem cell transplantation (SCT). These include the severity and duration of disease, donor-recipient HLA matching, stem cell source, and conditioning type. This interview took place at the 51st Annual Meeting of the EBMT in Florence, Italy.
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Transcript
I think the initial step is the initial disease and the status of the initial disease. So the longer the patient is suffering from complications, the more organ damage these patients have and this is less likely for the transplant to be successful. Also the type of donor, the HLA disparity and the matching is very important. And then the stem cell source and type is also very important...
I think the initial step is the initial disease and the status of the initial disease. So the longer the patient is suffering from complications, the more organ damage these patients have and this is less likely for the transplant to be successful. Also the type of donor, the HLA disparity and the matching is very important. And then the stem cell source and type is also very important. And then the donor recipient disparity in terms of the gender in our group. But there are also other factors such as the ABO, which is found in other groups to be very important. The type of the conditioning also is very important, whether or not to use a full myeloablative or reduced intensity transplant is also very important in this case.
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