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General Updates | Preventing and managing bone disease in patients with thalassemia
Julian Waung, BM, PhD, Whittington Hospital, London, UK, briefly comments on how to prevent bone disease in patients with thalassemia, emphasizing the importance of maximizing peak bone mass in early life and maintaining it as patients age. If bone disease does develop, Dr Waung highlights the importance of using anabolic treatment early on, if the patient is eligible for this. This interview took place virtually.
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Transcript
So I think the first plank is to try to build up as much bone as possible during the growth phase. So peak bone mass is reached in the late 20s and early 30s. So it’s about having adequate calcium intake, optimal hormone status, and exercise during youth so that the bones are as big as they can be, and then preserving that bone as much as possible again, with consideration of lifestyle factors and optimizing hormone status, and ensuring the patient is well chelated...
So I think the first plank is to try to build up as much bone as possible during the growth phase. So peak bone mass is reached in the late 20s and early 30s. So it’s about having adequate calcium intake, optimal hormone status, and exercise during youth so that the bones are as big as they can be, and then preserving that bone as much as possible again, with consideration of lifestyle factors and optimizing hormone status, and ensuring the patient is well chelated. So those would be the factors to prevent bone disease.
And then if intervention with medication is required, being confident to use pharmacological treatment, and there’s now a shift towards using anabolic treatment earlier if the patient qualifies for it, and it’s possible because we know that bone is built up more if they’ve not had lots of anti-resorptive, which is more conventional, treatment first.
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