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EHA 2021 | Skewed primary antigen-specific responses and chromatin remodelling of T-cells

Arnon Kater, MD, PhD, University of Amsterdam, Amsterdam, The Netherlands, discusses the skewed primary antigen-specific responses and chromatin remodelling of T-cells in a combined OT-I/TCL-1 adoptive transfer model for chronic lymphocytic leukemia (CLL). The study aimed to determine how CLL affects primary antigen-specific T-cell responses. Results from the study showed no significant difference in percentage of total leukemic OT-I cells (CD45.1+CD8+) in wild type and CLL mouse models. However, the T-cell phenotype in wild type mice was skewed by the induction of CLL. Skewing occurred more towards short-lived effector cells and there was an observed lower percentage of effector cells with a memory phenotype. There was also an associated increased expression of effector-related transcription factor T-bet as well as reduced expression of memory-related transcription factor BCL6. Extensive chromatin remodelling within OT-I cells in the CLL mice was also observed. The results from this study suggest a CLL-antigen independent effect on the antigen-specific immune response that drives T-cells towards phenotypes that deem them less functional. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.

Disclosures

Arnon Kater, MD, PhD, has participated in advisory boards and/or received research grants from Abbvie, BMS, Janssen, Roche/Genentech and Astra Zeneca; and has received speakers fees from Abbvie.

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