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CAR-T Meeting 2024 | Targeting BAFF-R with CAR-Ts to treat MCL

Mike Barnkob, MD, PhD, Odense University Hospital, Odense, Denmark, shares insights into the development of BAFF-receptor (BAFF-R)-specific CARs, which were investigated for the treatment of mantle cell lymphoma (MCL). While these CARs were able to kill primary MCL cells, relapse did occur, and Dr Barnkob highlights possible escape mechanisms. This interview took place at the EBMT-EHA 6th European CAR T-cell Meeting in Valencia, Spain.

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Disclosures

Consultancy fees: Kite/Gilead, Roche