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ASH 2022 | Hurdles to CAR-T therapy for MDS & AML: T-cell fitness & lack of a uniform target antigen
David Sallman, MD, Moffitt Cancer Center, Tampa, FL, outlines the current challenges in bringing CAR-T therapies to myeloid malignancies such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Dr Sallman highlights two concerns; the lack of a uniform target antigen, and poor T-cell fitness and function, the former he suggests could be overcome by developing cellular therapies targeting more than one antigen. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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Disclosures
Takeda: Consultancy; Shattuck Labs: Membership on an entity’s Board of Directors or advisory committees; Kite: Membership on an entity’s Board of Directors or advisory committees; Novartis: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Incyte: Speakers Bureau; Syndax: Membership on an entity’s Board of Directors or advisory committees; Magenta: Consultancy; Intellia: Membership on an entity’s Board of Directors or advisory committees; BMS: Membership on an entity’s Board of Directors or advisory committees, Speakers Bureau; Aprea: Membership on an entity’s Board of Directors or advisory committees, Research Funding; Agios: Membership on an entity’s Board of Directors or advisory committees; AbbVie: Membership on an entity’s Board of Directors or advisory committees; Syntrix Pharmaceuticals: Research Funding; Lixte: Patents & Royalties: LB-100; Nemucore: Membership on an entity’s Board of Directors or advisory committees
