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The Thalassemia Channel on VJHemOnc is an independent medical education platform, supported with funding from Agios (Gold). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
EBMT 2025 | Reviewing the literature on conditioning regimens for SCT in transfusion-dependent thalassemia
In this video, Mohammed Essa, MD, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, briefly discusses the evolution of conditioning regimens prior to stem cell transplantation (SCT) for patients with transfusion-dependent beta thalassemia, mentioning that he presented a review of the available literature on this topic at the EBMT 2025 meeting. This interview took place at the 51st Annual Meeting of the EBMT in Florence, Italy.
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Transcript
Actually, it was a great opportunity to go over the long history in conditioning regimens for transfusion-dependent beta thalassemia patients. That included, you know, for the last 30-40 years, going over the literature, especially at this meeting in the EBMT in Florence, in Italy, where a lot of patients with thalassemia were initially started and during that time until now we see the evolution of those variable conditioning regimens around the world...
Actually, it was a great opportunity to go over the long history in conditioning regimens for transfusion-dependent beta thalassemia patients. That included, you know, for the last 30-40 years, going over the literature, especially at this meeting in the EBMT in Florence, in Italy, where a lot of patients with thalassemia were initially started and during that time until now we see the evolution of those variable conditioning regimens around the world.
Myeloablative conditioning regimen has been always the standard of care in pediatrics as well as a lesser number of adult patients are being transplanted because of the intolerability of these kind of regimens. We reviewed that, you know, as time evolves, another type of transplants like haploidentical transplantation and matched unrelated transplantation has also been evolving in the field.
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