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ASH 2022 | Results from the MAJIC-PV trial: ruxolitinib vs BAT for hydroxyurea resistant/intolerant PV
Claire Harrison, MD, FRCP, FRCPath, Guy’s and St Thomas’s NHS Foundation Trust, London, UK, discusses results from the MAJIC-PV trial (ISRCTN61925716) of ruxolitinib vs best available therapy (BAT) for the treatment of hydroxyurea intolerant/resistant polycythemia vera (PV). Complete response (CR) and event-free survival (EFS) were significantly increased in the ruxolitinib group compared to the BAT group. A decrease in JAK2V617F allele fraction also correlated with increased EFS. This interview took place at the 64th ASH Annual Meeting and Exposition Congress held in New Orleans, LA.
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Disclosures
Geron: Membership on an entity’s Board of Directors or advisory committees; Keros: Consultancy; Constellation Pharmaceuticals, Inc., a MorphoSys Company: Membership on an entity’s Board of Directors or advisory committees, Research Funding; EHA: Other: Leadership role; MPN voice: Other: Leadership role; AbbVie: Membership on an entity’s Board of Directors or advisory committees; Incyte: Speakers Bureau; Shire: Membership on an entity’s Board of Directors or advisory committees; Sierra: Honoraria; AOP Pharma: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Promedior: Membership on an entity’s Board of Directors or advisory committees; Roche: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Gilead: Membership on an entity’s Board of Directors or advisory committees; Janssen: Membership on an entity’s Board of Directors or advisory committees; CTI BioPharma: Membership on an entity’s Board of Directors or advisory committees; Galecto: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Novartis: Membership on an entity’s Board of Directors or advisory committees, Other: Support for attending meetings, Research Funding; Galacteo: Membership on an entity’s Board of Directors or advisory committees; Celgene/BMS: Membership on an entity’s Board of Directors or advisory committees, Research Funding.
