Stephan Grupp, MD, PhD, Children’s Hospital of Philadelphia, Philadelphia, PA, outlines recent advances in the use of chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of lymphoid malignancies, highlighting real-world data. Dr Grupp discusses results from the Phase II ELIANA study (NCT02435849) investigating the efficacy and safety of CTL019 in pediatric patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). This interview took place during the 47th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT) 2021.