iwCLL 2023 | Optimizing initial therapy in CLL: time-limited, all-oral approaches

There’s a lot of activity in the research field for CLL to come up with treatments that are first chemotherapy free, I think we’ve achieved that, to make it time-limited, and provide a treatment that can not only control patients’ disease, but also give them the opportunity of being off treatment and hopefully for a long time. So the time-limited and maybe all oral therapy, it would be nice to avoid intravenous therapy and infusions, so I would say oral non-chemotherapy time-limited strategy, would be extremely helpful if we can come up with a regimen that can provide that. Now there are a number of clinical trials that are ongoing or planned, and we’re hoping that eventually that will be a treatment option for our patients. Of course we have a look at cure as well, so if these remissions are long enough that at least for the average age of CLL patients in their expected life, they don’t have a recurrence of CLL, we can maybe call it a functional cure, but the first step is to have long remission with these time-limited therapies.