In this video, Steven Pipe, MD, University of Michigan, Ann Arbor, MI, shares some updates from the Phase III HOPE-B trial, which is evaluating etranacogene dezaparvovec, an investigational gene therapy, in adult patients with severe or moderately severe hemophilia B (NCT03569891). In this study, patients with or without pre-existing AAV5 neutralizing antibodies received etranacogene dezaparvovec. Dr Pipe further discusses the results of this study, including factor IX activity, annualized bleed rate (ABR), and adverse events (AEs) observed. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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