Research has demonstrated that vitamin C plays a role in the activation of TET2, and patients with hematological malignancies are often deficient in vitamin C. In this presentation, Stine Ulrik Mikkelsen, MD, PhD, University of Copenhagen, Copenhagen, Denmark, discusses the Phase II EVI-2 study (NCT03682029), which evaluated the safety and efficacy of vitamin C supplementation in patients with low-risk myeloid malignancies and precursor conditions, including clonal cytopenia of undetermined significance (CCUS) and lower-risk myelodysplastic syndromes (LR-MDS). This press briefing took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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