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EHA 2025 | The importance of a trained multidisciplinary team when managing SCD and thalassemia

Maria Domenica Cappellini, MD, University of Milan, Milan, Italy, emphasizes the importance of a multidisciplinary approach in treating thalassemia and sickle cell disease (SCD), as these conditions lead to a cascade of complications affecting multiple organs. Prof. Cappellini emphasizes the importance of a comprehensive care team, comprising specialists from various fields, to address the disease and its treatment-related complications, such as iron overload. She stresses the importance of training these specialists to ensure they are equipped to provide optimal care for patients with these complex hematological diseases. This interview took place at the 30th Congress of the European Hematology Association (EHA) in Milan, Italy.

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Transcript

Well, you know, thalassemia and sickle cell disease, although they recognize, let’s say, baseline pathophysiology, which is due to the defect in the globin chain, but this is leading to a cascade of complications, not only hematological. So a cascade of complications involving many organs, either because of the disease per se or because of the treatment, because we are treating this patient with transfusions...

Well, you know, thalassemia and sickle cell disease, although they recognize, let’s say, baseline pathophysiology, which is due to the defect in the globin chain, but this is leading to a cascade of complications, not only hematological. So a cascade of complications involving many organs, either because of the disease per se or because of the treatment, because we are treating this patient with transfusions. Transfusions mean iron overload. Iron overload means damage to organs. So we have involved liver, heart, endocrine organs, and we need to treat this complication mainly due to toxicity of iron load or even other reasons. And for this reason, although we want to have someone who is taking care of the patients in a comprehensive way, but we need to have some specialists, for example, a pathologist, cardiologist, endocrinologist, and nowadays also a gynecologist or so on. What I want to underline is that this multidisciplinary team for a multidisciplinary approach requires having trained people. We cannot have a specialist from here and there. They need to be trained regarding the disease. We are working a lot on this during the last years because it is one of the main, let’s say, important achievements in treating these patients who are getting older.

 

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