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iwCLL 2025 | Outcomes with ven-based therapy in 1L or 2L high-risk CLL/SLL: a real-world international study
Catherine Coombs, MD, UC Irvine Health, Orange County, CA, discusses an international study evaluating the real-world treatment outcomes of patients with high-risk chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) receiving venetoclax (ven)-based therapy in the first-line (1L) or second-line (2L) setting. Although longer-term follow-up data are needed, Dr Coombs highlights that the efficacy of these regimens was promising in this patient population. This interview took place at the biennial International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2025 in Krakow, Poland.
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Transcript
So I’ll be presenting a poster looking at some real-world outcomes from patients who have higher-risk CLL, which is either unmutated IGHV and or TP53 aberrations, whether that’s a mutation in the gene or 17p deletion. And this was a large effort among 20-some academic institutions, mostly academic, all participating in this collaborative group called CORE...
So I’ll be presenting a poster looking at some real-world outcomes from patients who have higher-risk CLL, which is either unmutated IGHV and or TP53 aberrations, whether that’s a mutation in the gene or 17p deletion. And this was a large effort among 20-some academic institutions, mostly academic, all participating in this collaborative group called CORE. And so what we show is that you can actually attain pretty excellent outcomes even among high-risk patients who are treated in the front line with venetoclax-based regimens, most typically venetoclax with obinutuzumab, and we also look at this in the second line. Of course, longer follow-up is needed to understand the durability of these responses, but overall encouraging, suggesting that it is a reasonable approach to treat even the highest-risk patients with a time-limited regimen.
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Disclosures
AbbVie, AstraZeneca, BeOne Medicines, Lilly, Genentech, Janssen.
