Speaking the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition, held in San Diego, CA, Lindsey Roeker, MD, of the Memorial Sloan Kettering Cancer Center, New York City, NY, discusses her perspective on the challenges facing the treatment of chronic lymphocytic leukemia (CLL). Dr Roeker highlights the need to find the best treatment combinations in the front-line setting as a key area.