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ASH 2024 | PTCy-based GvHD prophylaxis in patients aged 70 and over: a BMT CTN 1703 post-hoc analysis

Sameem Abedin • 26 Nov 2024
ASH 2024
General Cyclophosphamide Methotrexate Tacrolimus
BMT CTN 1703

Sameem Abedin, MD, Medical College of Wisconsin, Milwaukee, WI, discusses outcomes of post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease (GvHD) prophylaxis in patients 70 years and older, highlighting a post-hoc analysis from the BMT CTN 1703 (NCT03959241) trial. This study found improved outcomes for patients treated with PTCy compared to tacrolimus and methotrexate, with no added toxicities. Dr Abedin emphasizes that PTCy should be considered standard GvHD prophylaxis in this age group. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.

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