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ASH 2024 | Real-world efficacy and safety of tisagenlecleucel in patients with R/R follicular lymphoma
Frederick Locke, MD, Moffitt Cancer Center, Tampa, FL, comments on the efficacy and safety of tisagenlecleucel (tisa-cel) in treating follicular lymphoma, noting a 90% objective response rate and 80% six-month progression-free survival in nearly 100 patients. Dr Locke, also highlights the manageable rates of cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and severe infections, with 60% experiencing CRS, 20% developing ICANS neurotoxicity, and 20% having severe infections. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Aptitude Health: Honoraria; American Society of Hematology: Honoraria, Other: travel, accomodation, expenses; BioPharma Communications CARE Education: Honoraria; A2: Consultancy; Allogene: Consultancy, Research Funding; Amgen: Consultancy; Bluebird Bio: Consultancy; Bristol-Myers Squibb: Consultancy, Research Funding; Calibr: Consultancy; Caribou: Consultancy; Kite, a Gilead Company: Consultancy, Other: institutional, travel, accomodation, expenses, Research Funding; Allogene: Other: Institutional, Research Funding; CERo Therapeutics: Research Funding; Moffitt Cancer Center: Patents & Royalties; Communications CARE Education: Honoraria; Clinical Care Options Oncology: Honoraria; Imedex: Honoraria; Society for Immunotherapy of Cancer: Honoraria; Cowen: Consultancy; EcoR1: Consultancy; Gerson Lehrman Group (GLG): Consultancy; Iovance: Consultancy; Janssen: Consultancy; Legend Biotech: Consultancy; Novartis: Consultancy, Research Funding; Sana: Consultancy; Umoja: Consultancy; Pfizer: Consultancy; 2SeventyBio: Other: Institutional, Research Funding; National Cancer Institute: Other: Institutional, Research Funding; Leukemia and Lymphoma Society Scholar in Clinical Research: Other: Institutional, Research Funding.
