CAR-T Meeting 2025 | Outcomes with CAR-T therapy in autoimmune diseases
In this video, Johanna Richter, Transplant Physician, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, discusses an update of data on the treatment of autoimmune diseases with CAR T-cell therapy from the University of Erlangen, which was presented at the European CAR T-cell Meeting 2025. The outcomes with CAR-T have been encouraging in several autoimmune diseases, including systemic lupus erythematosus (SLE) and myositis, and a new “immune cleansing” phenomenon was observed in a few cases. This interview took place at the EHA-EBMT 7th European CAR T-cell Meeting, held in Strasbourg, France.
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Transcript (AI-generated)
This year’s CAR-T meeting showed an update of the data on autoimmune diseases treated primarily in Erlangen, from the University of Erlangen. They treated nearly 40 patients up to this point and showed remarkable results with only one relapse in a myositis patient that they even continued on to treat with a second dose of CD19 CAR T-cells and then going on to a further treatment with BCMA CAR T-cells, so three times as a line of CAR T-cell treatment...
This year’s CAR-T meeting showed an update of the data on autoimmune diseases treated primarily in Erlangen, from the University of Erlangen. They treated nearly 40 patients up to this point and showed remarkable results with only one relapse in a myositis patient that they even continued on to treat with a second dose of CD19 CAR T-cells and then going on to a further treatment with BCMA CAR T-cells, so three times as a line of CAR T-cell treatment. They’ve shown remarkable results, but this was really interesting about this session in particular, in my opinion, was also that they commented on a new immune cleansing phenomenon. They showed it in a couple of patients with just a flare of like an isolated site of the autoimmune disease and they treated it with sometimes prednisolone and overall the results that are from the few clinical cases that we already gathered right now are pretty promising, especially in lupus and myositis and systemic sclerosis. So this is remarkable work.
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