In this video, Matthew Cortese, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, shares insights into a multi-omic study that used a combination of transcriptomics, RRBS, advanced flow cytometry, and metabolomics to analyze the effects of venetoclax on the immune system in 13 patients with chronic lymphocytic leukemia (CLL). Results showed significant T-cell repair and immune system recovery in patients treated with venetoclax, which could lead to improved outcomes with CAR T-cell therapy and other immunotherapies. This interview took place at the 66th ASH Annual Meeting and Exposition, held in San Diego, CA.
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