AACR 2024 | Investigating mutation order in AML using single-cell sequencing
Mutation order is an important feature of cancer development, particularly in the case of acute myeloid leukemia (AML). Ravindra Majeti, MD, PhD, Stanford University, Stanford, CA, presents the findings of a study investigating the mutation acquisition patterns in collated data from 130 patients with AML across several institutions. Dr Majeti highlights that canonical and non-canonical patterns of mutation acquisition were identified using single-cell DNA sequencing data. Although the patient cohort was not large enough to identify differences in clinical presentation, these results indicate that there may be significant individual differences in cell-of-origin, disease pathogenesis, and clinical outcomes. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2024 in San Diego, CA.
These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.
