Here, Stephan Grupp, MD, PhD, of the Children’s Hospital of Philadelphia, Philadelphia, PA, presents an update of ELIANA (NCT02435849), which investigated the now FDA-approved CD19-directed CAR T-cell product tisagenlecleucel – now with additional patients and a further 11 months follow-up since the previous report, from the American Society of Hematology (ASH) 2018 Annual Meeting and Exposition in San Diego, CA.