The Acute Myeloid Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from BMS (Silver), and through an educational grant from Jazz Pharmaceuticals. Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ESH AL 2018 | How can we improve CAR T-cell therapy?
Speaking from the 2018 European School of Hematology (ESH) Clinical Updates on Acute Leukemias, held in Budapest, Hungary, Marion Subklewe, MD, from LMU Hospital Munich, Munich, Germany, gives insight into the steps that can be taken to improve the effectiveness and safety of CAR T-cell therapy, including performing allogeneic stem cell transplants on the patient after CAR T-cell therapy to overcome hematotoxicity, and using smaller adaptor molecules, such as blinatumomab, in combination with universal CAR T-cell products to enhance overall efficacy. Dr Subklewe also expresses her excitement about the amount of CAR T-cell trials that are currently in development or underway.
