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iwCLL 2017 | Starving CLL cells of oxygen results in a new predictive test
Leopold Sellner, MD from the University Hospital Heidelberg, Heidelberg, Germany discusses his work on cultivating leukemia cells under anoxia for the identification of chronic lymphocytic leukemia (CLL) patients with aggressive clinical course and resistance to chemoimmunotherapy. Dr Sellner describes how the focus of his investigation was to look at the ratio of 3 enzymes of glycolysis under normoxic and anoxic conditions. The basis of the test was to assess the glycolytic capacity of tumour cells under anaerobic conditions known as the Warburg effect. This can be used to predict patients with aggressive disease as well as predict which patients will have poor response to chemoimmunotherapy. Dr Sellner explains how his findings now need to be validated in a larger cohort. He also explains how his findings will help physicians to choose treatments for patients according to their metabolic status. This interview was recorded at the International Workshop on Chronic Lymphocytic Leukemia (iwCLL) 2017 held in New York, NY
