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SOHO 2025 | Fertility preservation in patients with lymphoma
In this video, Ariela Noy, MD, Memorial Sloan Kettering Cancer Center, New York, NY, provides insight into fertility preservation in patients with lymphoma, highlighting the importance of early collaboration with specialized gynecologists. Dr Noy emphasizes the importance of considering fertility preservation for all patients, including those who already have children, and recommends options such as sperm banking for men and oocyte retrieval, ovarian tissue retrieval, and embryo freezing for women, as well as the use of leuprolide to potentially restart reproductive function following chemotherapy. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX.
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Transcript
Those are three very different areas. Let’s take them apart.
So for fertility preservation, the key is early collaborative work with gynecologists who specialize in that, when there is time. Obviously in men it’s much simpler. We just have to remember to tell them to do sperm banking, sometimes physicians forget...
Those are three very different areas. Let’s take them apart.
So for fertility preservation, the key is early collaborative work with gynecologists who specialize in that, when there is time. Obviously in men it’s much simpler. We just have to remember to tell them to do sperm banking, sometimes physicians forget. And you should ask, even if someone’s 40 and they have three kids, you know, you don’t know what their plans were. So you have to ask. For women, it’s very tricky. And another paper just came out in JAMA, I think 2023 or 24. Women who have gotten standard chemotherapies, once they hit age 35 in particular, it’s very unlikely that they will have normal fertility afterwards. So the younger patients, maybe they can get their menstrual cycles back, but they’re still at risk for early menopause. And one of the things that we do is working with the fertility experts is oocyte retrieval, sometimes in combination with ovarian tissue retrieval that can be frozen. Ideally, if the patient has a partner, then we can freeze embryos, which has the highest likelihood of success rate. For all patients, we also discuss leuprolide, which in mostly meta-analyses and some randomized trials has demonstrated the possibility that it allows the reproductive system to wake up after all is said and done with the chemotherapy and the leuprolide closing down of the hypothalamic ovarian axis.
This transcript is AI-generated. While we strive for accuracy, please verify this copy with the video.
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