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ISA 2024 | Doxycycline/TUDCA versus standard supportive therapy in transthyretin cardiac amyloidosis
Paolo Milani, MD, PhD, Amyloidosis Research and Treatment Center, Pavia, Italy, discusses a Phase III study (NCT03481972) which compared doxycycline and tauroursodeoxycholic acid (TUDCA) versus standard supportive therapy alone in transthyretin (ATTR) cardiac amyloidosis. The trial found that doxycycline did not improve survival in patients with wild-type ATTR amyloidosis. Despite the negative outcome, the study provides valuable insights into the natural history of this disease. This interview took place at the XIX International Symposium on Amyloidosis (ISA) in Rochester, MN.
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Disclosures
Honoraria: Pfizer, Jannsen-Cilag
Membership on Board of Directors or advisory committee: Jannsen-Cilag, Siemens
