Educational content on VJHemOnc is intended for healthcare professionals only. By visiting this website and accessing this information you confirm that you are a healthcare professional.

Share this video  

ASH 2016 | Results for trial of LCL161 for PMF, post-PV MF, and post-ET MF patients

Naveen Pemmaraju, MD of the MD Anderson Cancer Center, Houston, TX explains an ongoing Phase II clinical trial of LCL16 in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF) or post-essential thrombocytosis myelofibrosis (post-ET MF) (NCT02098161). LCL161 is a SMAC mimetic and antagonist of the inhibitor of apoptosis protein, and used for the first time for patients with these rare disorders in this study. Initial results have been encouraging, and the plan is to continue enrolling. Dr Naveen points to the possibility of immune system side effects. Recorded at Recorded at the 2016 American Society of Hematology (ASH) Annual Meeting, held in San Diego, CA.