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EHA 2024 | Results from a Phase I/II study of golcadomide in R/R follicular lymphoma

Julio Chavez, MD, MS, Moffitt Cancer Center, Tampa, FL, outlines the results from a Phase I/II study (NCT03930953) of golcadomide, a cereblon E3 ligase modulator (CELMoD), in 31 patients with relapsed/refractory (R/R) follicular lymphoma (FL). Despite the study being conducted in a high-risk patient population, an overall response rate (ORR) of 70% and a complete response (CR) rate of 40% were observed. The agent was well tolerated, and any cases of cytopenia and neutropenia were managed with supportive care, such as growth factors. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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Disclosures

Consulting: Genmab, Kite, Novartis, BMS, Allogene.