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SOHO 2025 | Novel agents showing promise for the treatment of double-refractory CLL

Meghan Thompson, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses emerging classes of agents being explored for relapsed chronic lymphocytic leukemia (CLL), highlighting the focus on patients who are double-refractory. Dr Thompson notes that non-covalent BTK inhibitors, BTK degraders, and bispecific antibodies are being developed, with some agents showing promise in early-phase trials. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX.

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