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ESH CML 2022 | Gene knockdown strategies to investigate the properties of leukemic stem cells

Andrew Wu, BS, MS, British Columbia Cancer Agency, Vancouver, Canada, outlines different gene knockdown methods that can be used to investigate the properties of leukemic stem cells (LSCs), including short hairpin RNA (shRNA)-mediated gene silencing, CRISPR/Cas9-mediated knockdown, and using lipid nanoparticles for small interfering (siRNA) delivery. This interview took place at the 24th Annual John Goldman Conference on Chronic Myeloid Leukemia (ESH CML) held in Mandelieu-La Napoule, France.

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