The Chronic Lymphocytic Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), AbbVie (Platinum), BeOne Medicines (Silver) and Lilly (Silver). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
The Lymphoma Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), BMS (Gold), Johnson & Johnson (Gold), Takeda (Silver) and Galapagos (Bronze). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ICML 2023 | Efficacy and safety of glofitamab for patients with Richter’s transformation
Richter’s transformation (RT) is characterized by the development of an aggressive lymphoma, usually diffuse large B-cell lymphoma (DLCBL), in a patient with underlying chronic lymphocytic leukemia (CLL). This patient population has very poor outcomes and represents an area of high unmet medical need. Carmelo Carlo-Stella, MD, PhD, Humanitas Clinical and Research Center, Rozzano, Italy, discusses the inclusion of patients with RT in the NP30179 trial (NCT03075696), investigating glofitamab as a single agent therapy for relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL). Prof. Carlo-Stella shares the promising efficacy and safety data from this patient cohort, in which four out of the five patients who achieved a complete remission (CR) remained in CR at data cutoff. This interview took place at the 17th International Conference on Malignant Lymphoma (ICML), held in Lugano, Switzerland.
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Disclosures
Consultant or advisory role ADC Therapeutics, Celgene/Bristol Myers Squibb, Karyopharm, Novartis, Sanofi, Roche, Merck Sharp & Dohme, Scenic Biotech
Honoraria: Merck Sharp & Dohme, Janssen Oncology, AstraZeneca, Celgene, Incyte, Gilead Sciences, Roche
