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EHA 2024 | Overcoming off-target toxicities associated with CAR-Ts in AML

Alex Bataller, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, discusses the challenge of using CAR T-cells in acute myeloid leukemia (AML) due to shared targets on both AML cells and healthy cells. He suggests that the next steps involve modifying CAR constructs or hematopoietic progenitors to avoid off-target toxicities. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.

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