Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, discusses the growing importance of analyzing genetic abnormalities in patients with chronic lymphocytic leukemia (CLL). Beyond the traditional use of next-generation sequencing (NGS) at the time of progression, emerging data suggest that abnormalities in genes involved in BCR signaling, epigenetic regulation, and transcriptional factors may impact time-to-first treatment, helping to identify patients who require closer follow-up or may be candidates for early intervention. This interview took place at the 13th Annual Meeting of the Society of Hematologic Oncology (SOHO 2025) in Houston, TX.
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