ASH 2023 | The MOST study: differences in disease progression amongst patients with low-risk MF
Aaron Gerds, MD, Cleveland Clinic, Cleveland, OH, comments on the Myelofibrosis and Essential Thrombocythemia Observational Study (MOST; NCT02953704), which aimed to investigate the spectrum of disease within myeloproliferative neoplasms (MPNs), specifically focusing on the transition of patients between low-risk myelofibrosis (MF) and essential thrombocythemia (ET). The study’s findings elucidated that some patients with low-risk MF progress to a higher-risk disease state much more rapidly than others, indicating two distinct trajectories of the disease. Dr Gerds highlights the need to observe the molecular mechanisms responsible for the varying rates of progression to better understand the drivers of the disease. This interview took place at the 65th ASH Annual Meeting and Exposition, held in San Diego, CA.
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Disclosures
Consultancy: AbbVie, Bristol Myers Squibb, Constellation Pharmaceuticals, GlaxoSmithKline, Kartos, Novartis, PharmaEssentia, Sierra Oncology
Research Funding: Accurate Pharmaceuticals, Constellation Pharmaceuticals, CTI BioPharma, Imago BioSciences, Incyte Corporation, Kratos Pharmaceuticals
