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IPIG 2025 | Pregnancy in patients with PNH: important considerations prior to conception and during pregnancy
Yara Aldosari, hematology fellow at King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, discusses clinical considerations for managing pregnancy in patients with paroxysmal nocturnal hemoglobinuria (PNH). She highlights the importance of considering the risks associated with pregnancy prior to conception, and emphasizes the need for a stable disease state, compliance with treatment, and administration of anticoagulation therapy to mitigate the increased thrombosis risk during pregnancy. This interview took place at the 2nd International PNH Interest Group (IPIG) Conference in Paris, France.
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Transcript
The first thing, pregnancy should be avoided with PNH patients. However, you know, any lady wants to have children. So once they get pregnant, the first thing they have to know before even getting conception is the risks of being pregnant, the importance of compliance, and another important factor, the state of their disease should be in a stable condition before even getting pregnant...
The first thing, pregnancy should be avoided with PNH patients. However, you know, any lady wants to have children. So once they get pregnant, the first thing they have to know before even getting conception is the risks of being pregnant, the importance of compliance, and another important factor, the state of their disease should be in a stable condition before even getting pregnant. The next step is to actually refer them to a high-risk pregnancy clinic, which is a joint clinic between the hematologist and also the obstetrician, and also a social worker to be involved to actually follow up with those patients. The last thing we have to make sure about is their thrombosis risk, which will be doubled during pregnancy, given that pregnancy itself is a hypercoagulable state along with the PNH disease itself. So this patient should actually be on anticoagulation and they should be compliant with the PNH medication, which is eculizumab, as stated in our report.
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