The Chronic Lymphocytic Leukemia Channel on VJHemOnc is an independent medical education platform, supported with funding from AstraZeneca (Diamond), AbbVie (Platinum), BeOne Medicines (Silver) and Lilly (Silver). Supporters have no influence on the production of content. The levels of sponsorship listed are reflective of the amount of funding given.
ERIC 2020 | The history of understanding CLL B-cell genes
Freda Stevenson, MSc, DPhil, FRCPath, FMedSci, University of Southampton, Southampton, UK, discusses how our understanding of chronic lymphocytic leukemia (CLL) has developed over the past 20 years. Research investigating immunoglobulin genes in human B-cell tumors did not start until the 1990s and required the knowledge of B-cell gene structure and somatic hypermutation. Importantly, the library of genes that are available today enabled a deeper understanding of B-cell genes in CLL, their origins and if they were somatically mutated. This interview took place during the European Research Initiative on CLL (ERIC) International Virtual Meeting 2020.
