Michael Spencer Chapman, MBBS, Wellcome Sanger Institute, Cambridge, UK, discusses findings from a study which analyzed real-world data (RWD) to understand the survival and engraftment of stem cells after allogeneic stem cell transplantation (alloSCT). Dr Chapman explains the sequencing technologies used in this study to create a family tree of the transplanted blood system. This study allowed researchers to discover the estimated number of transplanted cells that survive once in the recipient, and also identified factors which may impact this value. Data on the diversity of clonal makeup and genomic alterations are also mentioned, and Dr Chapman highlights the possibility of using these findings to enhance stem cell transplantation procedures in the future. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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