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IWWM-12 2024 | Silencing GNAS to improve the efficacy of HDAC3 inhibitors in DLBCL and FL with wild-type CREBBP
Patrizia Mondello, MD, PhD, Mayo Clinic, Rochester, MN, discusses a study investigating the efficacy of HDAC3 inhibition in patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, dependent on the presence of CREBBP mutations. The study found that silencing the GNAS gene could improve the efficacy of HDAC3 inhibitors, which are less effective in patients with wild-type CREBBP. This interview took place at the 12th International Workshop on Waldenström’s Macroglobulinemia (IWWM-12) in Prague, Czech Republic.
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