Francesco Forconi, MD, DM, PhD, FRCPath, University of Southampton, Southampton, UK, gives an overview of two abstracts presented at BSH 2022 in the lymphoma and chronic lymphocytic leukemia (CLL) session. Dr Forconi first discusses an abstract presented by Dr Talha Munir and Prof. Peter Hillmen on sudden death and higher rates of cardiac toxicity associated with Bruton’s tyrosine kinase (BTK) inhibitors. Dr Forconi then highlights another session which focused on the effects of the COVID-19 pandemic on CLL patients, and further discusses vaccine responses in these immunosuppressed patients. This interview took place at the 62nd Annual Scientific Meeting of the British Society for Haematology (BSH) 2022, in Manchester, UK.