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ASH 2022 | Prolonged & continuous transfusion independence after imetelstat treatment in the IMerge trial

Rami Komrokji, MD, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, discusses the use of imetelstat for the treatment of myelodysplastic syndromes (MDS), which is currently under investigation in the Phase II IMerge trial (NCT02598661). In this study, imetelstat achieved prolonged transfusion independence (TI) in patients with lower-risk MDS who were non-del(5q) and lenalidomide/hypomethylating agent (HMA)-naïve. Imetelstat also demonstrated an encouraging safety profile and results suggest that this agent may have disease-modifying activity, providing a valuable therapeutic option for patients. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Jazz: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Speakers Bureau; PharmaEssentia: Honoraria, Other, Speakers Bureau; CTI biopharma: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Speakers Bureau; Servio: Honoraria, Membership on an entity’s Board of Directors or advisory committees, Speakers Bureau; BMS: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Abbvie: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Geron: Honoraria, Membership on an entity’s Board of Directors or advisory committees; Taiho: Honoraria, Membership on an entity’s Board of Directors or advisory committees.