Sascha Haubner, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, discusses the rationale for a chimeric antigen receptor (CAR) designed to target both ADGRE2 and CLEC12A in order to enhance anti-leukemic efficacy without increasing toxicity in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML). ADGRE2 and CLEC12A are both highly co-expressed in AML, but with low levels of overlapping expression in normal cells. This interview took place at the virtual European Hematology Association (EHA) Congress 2021.