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ASH 2022 | Phase I study of costimulatory bispecific antibody RO7227166 combined with glofitamab in R/R B-NHL

Martin Hutchings, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, describes the findings of the Phase I BP41072 study (NCT04077723) that investigated the safety of combination therapy with CD19- and 4-1BB-targeting bispecific monoclonal antibody RO7227166 and glofitamab in patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL). This study demonstrated that this combined treatment regimen was tolerable, with no increased risk of adverse events detected. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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Celgene: Consultancy, Research Funding; Novartis: Research Funding; Genmab: Consultancy, Research Funding; Genentech: Research Funding; Janssen: Consultancy, Research Funding; Incyte: Research Funding; Roche: Consultancy, Research Funding; Takeda: Consultancy, Research Funding; AbbVie, Celgene, Genmab, Janssen, Roche, Takeda: Membership on an entity’s Board of Directors or advisory committees; Celgene, Genentech, Genmab, Incyte, Janssen, Novartis, Roche, Takeda: Research Funding; AbbVie: Consultancy.