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MPN Workshop of the Carolinas 2025 | Improving the diagnosis and classification of MPNs
In this video, Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, suggests that the current approach to diagnosing and classifying myeloproliferative neoplasms (MPNs) could be improved by incorporating the features of the bone marrow immune microenvironment into formal pathology reports. This could provide a more comprehensive understanding of the disease, enabling treating physicians to make more informed decisions. This interview took place at the 2nd Annual MPN Workshop of the Carolinas, held in Charlotte, NC.
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Transcript
I think, you know, there’s a lot of room for improvement, in the diagnosis of MPNs. Traditionally, we’ve really focused on bone marrow morphology, including megakaryocyte morphology, hypercellularity, and fibrosis. But we know, as you know, has come up in the meeting several times today already, that the immune microenvironment in the bone marrow of patients with myeloproliferative neoplasm is heavily altered...
I think, you know, there’s a lot of room for improvement, in the diagnosis of MPNs. Traditionally, we’ve really focused on bone marrow morphology, including megakaryocyte morphology, hypercellularity, and fibrosis. But we know, as you know, has come up in the meeting several times today already, that the immune microenvironment in the bone marrow of patients with myeloproliferative neoplasm is heavily altered. And this is an area of extensive research and interest, but it’s really something that we don’t take into account diagnostically in terms of classification. So I think we could do a lot better with incorporating the features of the immune microenvironment of the bone marrow into formal pathology reports, giving a more structured type report and information to the treating physicians. And again, I think we know a lot about the microenvironment at this point, and we do have the tools to characterize it. It’s just a matter of bringing it to the clinic.
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