EBMT 2025 | The evaluation of cognitive impairment and neurotoxic effects in adult patients receiving CAR-T
In this video, Evlampia Strongyli, RN, MSc, PGDip (edu), PhD, George Papanikolaou General Hospital, Thessaloniki, Greece, briefly comments on the evaluation of cognitive impairment and neurotoxic effects in adult patients undergoing CAR T-cell therapy. She highlights the importance of administering cognitive tests, such as the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE), both before and after infusion, to assess any cognitive effects of the therapy. This interview took place at the 51st Annual Meeting of the EBMT in Florence, Italy.
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Transcript
Where I work our team, actually we are searching for cognitive actions according to the adult patients to whom we administer the CAR T-cell therapy. We frame them with two tests, MoCA, the Montreal Cognitive Assessment Test, and the Mini-Mental State Examination test. We administer these tests before the therapy, the CAR-T therapy, post infusion also at six hours, three months also as a follow-up and six months...
Where I work our team, actually we are searching for cognitive actions according to the adult patients to whom we administer the CAR T-cell therapy. We frame them with two tests, MoCA, the Montreal Cognitive Assessment Test, and the Mini-Mental State Examination test. We administer these tests before the therapy, the CAR-T therapy, post infusion also at six hours, three months also as a follow-up and six months.
So far we checked 30 patients and we checked their neurotoxic effects that they are going through and also the cognitive actions. And our conclusion is that the early post infusion time is the time that these grades are declined. These two tests are very useful for clinical practice and benefit, and help us, both team doctors and nurses, for our assessment.
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