Coagulation Disorders

Coagulation disorders are diseases that result in bleeding or obstructive clotting. There are several components involved coagulation or clotting. These include platelets and coagulation factors. Dysfunction or deficiency in either of these can either result in excessive bleeding due to failure of clotting mechanisms such as Haemophilia or thrombocytopenia. Dysfunction or excess of these factors can lead to thrombosis such as thrombocytosis or factor V Leiden. Coagulation disorders are related to haematological malignancies due to the very fact that they disrupt the composition of blood, leading to an increase or decrease in components vital for normal coagulation.